Cortopassi Lab-Driven and Collaborative Publications from the last 10 years.

A full list can be found on PubMed under "Cortopassi G"



 Name of Paper (Click name for description and full access   to paper)

Feb, 2024Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer's mouse model and stimulates synaptic plasticity pathway enzymes

Feb, 2024Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used.

Jan, 2024Mitochondria dysfunction induced by decyl-TPP mitochondriotropic antioxidant based on caffeic acid AntiOxCIN6 sensitizes cisplatin lung anticancer therapy due to a remodeling of energy metabolism.
Nov, 2023The ketone body β-hydroxybutyrate shifts microglial metabolism and suppresses amyloid-β oligomer-induced inflammation in human microglia.
May, 2023Quaternary Ammonium Compounds: A Chemical Class of Emerging Concern.

Jan, 2023Androgen receptor-dependent regulation of metabolism in high grade bladder cancer cells.

Sep, 2022Shc Is Implicated in Calreticulin-Mediated Sterile Inflammation in Alcoholic Hepatitis.

​May, 2022A Drug Combination rescues Frataxin-Dependent Neural and Cardiac Pathophysiology in FA Models
 Nov, 2021The Histone H3 K4me3, K27me3, and K27ac Genome-Wide Distributions Are Differently Influenced by Sex in Brain Cortexes and Gastrocnemius of the Alzheimer's Disease PSAPP Mouse Model

​ Aug, 2021

Shc inhibitor idebenone ameliorates liver injury and fibrosis in dietary NASH in mice.
  Jun, 2021Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter.
 May, 202117-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex.
​ Mar, 2021Altered toxicological endpoints in humans from common quaternary ammonium compound disinfectant exposure.
​ Mar, 2021A ketogenic diet impacts markers of mitochondrial mass in a tissue specific manner in aged mice.
 Feb, 2021Dimethyl fumarate dose-dependently increases mitochondrial gene expression and function in muscle and brain of Friedreich's ataxia model mice.
​ Jan, 2021Repurposing FDA approved drugs inhibiting mitochondrial function for targeting glioma-stem like cells.
 Nov, 2020 Novel mTORC1 Inhibitors Kill Glioblastoma Stem Cells
 Oct, 2020Novel idebenone analogs block Shc's access to insulin receptor to improve insulin sensitivity
 Jan, 2020Non-phagocytic Activation of NOX2 Is Implicated in Progressive Non-alcoholic Steatohepatitis During Aging
 Nov, 2019PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host-microbe intersection during SIV infection
 Oct, 2019Potential biomarker identification for Friedreich's ataxia using overlapping gene expression patterns in patient cells and mouse dorsal root ganglion
 Oct, 2019Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer
 Jun, 2019​Dimethyl fumarate dosing in humans increases frataxin expression: A potential therapy for Friedreich's Ataxia
 Oct, 2018Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition
 Sep, 2018Small molecules bind human mTOR protein and inhibit mTORC1 specifically
 May, 2018A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice
 Jan, 2018​Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative
 Sep, 2017A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice
 Aug, 2017In Vitro Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride
 Aug, 2017Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans
 Apr, 2017The Eye Drop Preservative Benzalkonium Chloride Potently Induces Mitochondrial Dysfunction and Preferentially Affects LHON Mutant Cells
 Apr, 2017Frataxin Deficiency Impairs Mitochondrial Biogenesis in Cells, Mice and Humans
 Feb, 2017Bipolar cell reduction precedes retinal ganglion neuron loss in a complex 1 knockout mouse model
 Dec, 2016Galectin-3 regulates inflammasome activation in cholestatic liver injury
 Dec, 2016Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism
 Oct, 2016A high-throughput screen for mitochondrial function reveals known and novel mitochondrial toxicants in a library of environmental agents
 Sep, 2016Mice with low levels of Shc proteins display reduced glycolytic and increased gluconeogenic activities in liver
 Sep, 2016Identification of small molecules that improve ATP synthesis defects conferred by Leber's hereditary optic neuropathy mutations
 Aug, 2016Neurobehavioral deficits in the KIKO mouse model of Friedreich's ataxia
 June, 2016Lactate and Pyruvate Are Major Sources of Energy for Stallion Sperm with Dose Effects on Mitochondrial Function, Motility, and ROS Production
 June, 2016p46Shc Inhibits Thiolase and Lipid Oxidation in Mitochondria
 May, 2016Mitochondrial oxygen consumption is a unique indicator of stallion spermatozoal health and varies with cryopreservation media
 Apr, 2016Lymphoblast Oxidative Stress Genes as Potential Biomarkers of Disease Severity and Drug Effect in Friedreich's Ataxia
 Mar, 2016Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34
 Dec, 2015Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly
 Nov, 2015Oxidative stress in inherited mitochondrial diseases
 Apr, 2015Key Glycolytic Enzyme Activities of Skeletal Muscle Are Decreased under Fed and Fasted States in Mice with Knocked Down Levels of Shc Proteins
 Feb, 2015Dysregulation of glutamine transporter SNAT1 in Rett syndrome microglia: a mechanism for mitochondrial dysfunction and neurotoxicity
 Feb, 2015Mitochondrial complex I deficiency leads to inflammation and retinal ganglion cell death in the Ndufs4 mouse
 Nov, 2014Mitochondrial complex I defects increase ubiquitin in substantia nigra
 Sept, 2014Shc depletion stimulates brown fat activity in-vivo and in-vitro
 Aug, 2014Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia
 Aug, 2014Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia
 July, 2014High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects
 Mar, 2013Frataxin deficiency leads to defects in expression of antioxidants and Nrf2 expression in dorsal root ganglia of the Friedreich's ataxia YG8R mouse ...
 Feb, 2013Effects of alkyl side chain modification of coenzyme Q10 on mitochondrial respiratory chain function and cytoprotection
 Dec, 2012Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries
 Oct, 2012OPA1 Mutation and Late-Onset Cardiomyopathy: Mitochondrial Dysfunction and mtDNA Instability
 Sept, 2012Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression
 June, 2012Shc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis
 May, 2012Hepatic Src homology phosphatase 2 regulates energy balance in mice
 Dec, 2011HSC20 interacts with frataxin and is involved in iron-sulfur cluster biogenesis and iron homeostasis
 Dec, 2011The p66Shc knocked out mice are short lived under natural condition
 Nov, 2010The Shc locus regulates insulin signaling and adiposity in mammals
 Aug, 2010Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria